Tom Hardy as Edward Brock Jr./Venom-a former reporter turned Anti Hero when bonded to a symbiote from space.
Tim Curry as the Venom Symbiote-The symbiote that bonded with Eddie Brock.
Reid Scott as Carlton Drake-a Egotistical Board Director for The Life Foundation who creates the Life Foundation Symbiotes.
Michelle Williams as Ann Weying-a district Attorney and the Love interest of Eddie Brock.
Patrick Schwarzenegger as Trevor Cole/Riot-The most agressive of the Mercs turned symbiotes hosts and is able to create bludgeoning weapons from his hands.
Charlotte Hegele as Donna Diego/Scream-a schizophrenic mercenary who is able to use her symbiote hair to attack people.
Zane Holtz as Carl Mach/Phage-The Leader of the Life Foundation Symbiotes and is able to create serrated blades from his hands.
Aubrey Plaza as Leslie Genesria/Agony-a Life Foundation Symbiote who is able to spit Acid at Aggressors.
Riz Ahmed as Ramon Hernandez/Lasher-a Life Foundation Symbiote who is able to use Symbiote activated Whip Tendrils
Jackie Earle Haley as Cletus Kasady(cameo)-a serial Killer and psychopath.
Idris Elba as General Orwell Taylor-The leader of the Jury and a General of the U.S army who teams up with Venom to Take down the other Symbiotes.
Tom Holland as Peter Parker/Spider Man(Cameo)
Maisie Williams as Mary Jane Watson(Cameo)