This is the sequel to The Spectacular Spider-Man. It stars Christoph Waltz as Dr. Curt Connors/The Lizard, Patrick Fugit reprising his role as Peter Parker/Spider-Man, and Gerard Butler as Kraven.
Mysterio contaminated Dr. Connors Lizard serum to regenerate his arm, but forgot to test it out, he injected it into the nub where his arm was, and grew it back, but it was a lizard arm, he transformed into The Lizard. Spider-Man stopped him and he turned back. Later, Dr. Elizi Calypso is exploring the jungle for new life-forms, when her guide, Sergei Kravenoff is nearly torn apart by a lion. She has no hope but to inject him with the untested serum called "Regenics." He heals within 10 hours. He also gains super strength, speed, and agility. He also has enhanced scenting abilities, plus animal insincts. He is now obsessed with using these abilities. He becomes Kraven the Hunter. Kraven hears about a Lizard-Man in Manhattan and boards a plane to get there, so he can test his hunting abilities. He sniffs his way to Dr. Connors lab, with lizard scent all over it. Kraven breaks in, and Spider-Man hears the security alarm go off, and swings to the lab. He then battles Kraven until he disappears into the night. Later, Dr. Connors wife, Martha, dies of radiation poisoning. Before Billy dies of it Curt sends him to live with Martha's sister. Later, he turns into The Lizard out of rage. Spider-Man fights him and cures him. Billy comes home because the radiation is gone. Later, Kraven confronts Connors. Connors nervously walks backwards until he trips and falls backward into a vat of the Lizard serum. Kraven thinks he killed the doctor, so he leaves. Until he crawls out as The Lizard, now stronger from the overdose. Lizard viciously attacks Kraven and goes on a rampage. kraven must team up with Spider-Man to stop The Lizard. Later, Dr. Connors dies from the overdose and then Spidey sneaks up on Kraven and gives him the cure to the Regenics. After the ending credits Kraven is shown getting freed from The RAFT because he is normal again. But it then shows him sneaking into the storage room and swiping a booster shot of Regenics. The screen fades out and Kraven can be heard sayin "The Hunt... Is On!"
- Patrick Fugit - Peter Parker/Spider-Man
- Christoph Waltz - Dr. Connors/The Lizard
- Gerard Butler - Sergei Kravenoff/Kraven The Hunter
- Heather Graham - Felicia Hardy